| ncRNA name | ANRIL |
| ncRNA Category | lncRNA |
| ID | 100048912 |
| Ensembl | ENSG00000240498 |
| Synonyms | CDKN2B-AS1, CDKN2B-AS, CDKN2BAS, NCRNA00089, PCAT12, RP11-145E5.4, p15AS |
| Disease name | cataract |
| Species | Homo sapiens |
| Tissues/Cell_line | human lens epithelial cell line SRA01/04 |
| Methods | shRNA knockdown, cytotoxicity assay, apoptosis assay, qRT-PCR, Western blot |
| Expression pattern | up-regulated |
| Functional description | Tanshinone IIA protects SRA01/04 cells from apoptosis triggered by H2O2. The expression of lncRNA ANRIL was upregulated by Tanshinone IIA. And, the protective effects of Tanshinone IIA on H 2 O 2 -stimulated SRA01/04 cells were abolished when lncRNA ANRIL was silenced. |
| PubMed ID | 30701534 |
| Year | 2019 |
| Title | Tanshinone IIA protects lens epithelial cells from H2 O 2 -induced injury by upregulation of lncRNA ANRIL. |
| Drug-related ncRNA | YES (Tanshinone IIA) |
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